Literature on Psoriatic Arthritis

Related ArticlesPsoriatic arthritis: genetic susceptibility and pharmacogenetics.

Pharmacogenomics. 2008 Feb;9(2):195-205

Authors: Rahman P, O’Rielly DD

Psoriatic arthritis (PsA) is an inflammatory arthritis associated with psoriasis. The etiology of PsA is unknown; however, there is mounting evidence for a strong genetic contribution to PsA. A few disease-related genes have already been identified in PsA. Cytokines associated with PsA appear to be the most promising targets for pharmacogenetics. Blockade of TNF-alpha and IL-12/23 is associated with a marked clinical response to PsA and/or psoriasis, implying a pivotal role of these cytokines in the pathogenesis of these two disease entities. To date, only the -308 variant of the TNF-alpha promoter gene has been shown to be important in predicting response to TNF-alpha blockade in inflammatory arthritis.

PMID: 18370848 [PubMed - indexed for MEDLINE]

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